在小鼠脑中人类tau株的朊病毒样传播
研究人员发现，人类tau蛋白株可以通过类似朊病毒的方式在小鼠大脑中传播，这可能为阿尔茨海默病等神经退行性疾病的新的见解提供可能。
为什么重要. 这一发现可能有助于更好地理解神经退行性疾病的机制，并可能带来新的治疗方法。
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证据
- NNature研究机构2026-09-30
Most neurodegenerative diseases are thought to spread through the brain by prion-like mechanisms, in which filamentous protein assemblies self-propagate by tem…
- NNature研究机构2026-09-30
However, it has so far not been shown that tau folds lead to distinct diseases by prion-like mechanisms and that conformational strains retain their identity o…
- NNature研究机构2026-09-30
We provide evidence for the prion-like transmission of human disease-specific tau strains in the mouse brain. Because the mouseand human tau sequences are iden…