Researchers have found that human tau protein strains can be transmitted in a prion-like manner in mouse brains, potentially leading to new insights into neurodegenerative diseases like Alzheimer's.
Why it matters. This discovery could lead to a better understanding of the mechanisms behind neurodegenerative diseases and potentially new treatments.
Most neurodegenerative diseases are thought to spread through the brain by prion-like mechanisms, in which filamentous protein assemblies self-propagate by tem…
However, it has so far not been shown that tau folds lead to distinct diseases by prion-like mechanisms and that conformational strains retain their identity o…
We provide evidence for the prion-like transmission of human disease-specific tau strains in the mouse brain. Because the mouseand human tau sequences are iden…
